Volume 32, No 8, Aug 2022

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 32 Issue 8, August 2022: 711-712

RESEARCH HIGHLIGHTS

GLP-1 appetite control via intestinofugal neurons

Nick J. Spencer^* , Tim J. Hibberd

Visceral Neurophysiology Laboratory, College of Medicine and Public Health, Flinders Health and Medical Research Institute, Flinders University, Bedford Park, South Australia, Australia
Correspondence: Nick J. Spencer(nicholas.spencer@flinders.edu.au)

The gut hormone glucagon-like peptide-1 (GLP-1) holds significant therapeutic interest for glycaemic and appetite control, but an endocrine role has been questioned, since GLP-1 is broken down rapidly in the bloodstream. A major new study by Zhang et al., identifies that a unique neuronal population within the enteric nervous system, whose axons leave the gut wall and activate sympathetic prevertebral neurons, links intestinal GLP-1 to gastric distension and acute appetite suppression, that characterizes a gastrointestinal behavior known as the “ileal brake”.

https://doi.org/10.1038/s41422-022-00692-0

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