Volume 32, No 9, Sep 2022

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 32 Issue 9, September 2022: 799-800

RESEARCH HIGHLIGHTS

Treatment for giant congenital nevi moves a step closer

Joanna Pozniak^1,2 , Jean-Christophe Marine^1,2,*

¹Laboratory for Molecular Cancer Biology, VIB Center for Cancer Biology, VIB, Leuven, Belgium
²Oncology Department, KU Leuven, Leuven, Belgium
Correspondence: Jean-Christophe Marine(jeanchristophe.marine@kuleuven.be)

Giant congenital melanocytic nevus, defined as a pigmented melanocytic lesion present at birth that will reach a diameter of ≥ 20 cm in adulthood, is associated with severe complications including malignant transformation into cutaneous melanoma, affects the central nervous system (neurocutaneous melanosis), and has major psychosocial impact due to its unsightly appearance. In a study recently published in Cell, Choi et al. used three mouse preclinical models to search for new non-invasive treatments, describing a promising strategy that promotes the clearing of these pigmented lesions by the innate immune system
https://doi.org/10.1038/s41422-022-00691-1

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