Volume 32, No 11, Nov 2022

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 32 Issue 11, November 2022: 961-962

RESEARCH HIGHLIGHTS

Promoting T and NK cell attack: preserving tumor MICA/B by vaccines

Frank Cichocki , Jeffrey S. Miller^*

Department of Medicine, University of Minnesota, Minneapolis, MN, USA
Correspondence: Jeffrey S. Miller(mille011@umn.edu)

The activating receptor NKG2D, first discovered in the late 1990’s, participates in the immune surveillance of cytotoxic lymphocytes through recognition of the stress-induced ligands MICA/B on the surface of malignant cells. Recently, a study by Badrinath et al. in Nature described a vaccine targeting approach that prevents proteolytic cleavage of MICA/B, leading to enhanced immune infiltration and antitumor responses highlighting the importance of NKG2D interactions on both natural killer cells and T cells.

https://doi.org/10.1038/s41422-022-00696-w

FULL TEXT | PDF

Browse 292