Volume 32, No 9, Sep 2022

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 32 Issue 9, September 2022: 843-854   |  Open Access

ORIGINAL ARTICLES

Glutamate drives ‘local Ca2+ release’ in cardiac pacemaker cells

Duanyang Xie^1,2,3,† , Ke Xiong^1,2,3,† , Xuling Su^2,3,† , Guanghua Wang^2,3,† , Qicheng Zou^1,2,3,† , Luxin Wang^1,2,3 , Caihong Zhang^2,4 , Yuting Cao^2,4 , Beihua Shao^2,4 , Yixin Zhang^2,4 , Peidong Zhang^2,4 , Dandan Liang^1,2,3 , Yi Liu^1,2,3 , Yi-Han Chen^1,2,3,5,6,*

¹Department of Cardiology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China
²Key Laboratory of Arrhythmias of the Ministry of Education of China, Tongji University School of Medicine, Shanghai, China
³Institute of Medical Genetics, Tongji University, Shanghai, China
⁴Jinzhou Medical University, Jinzhou, Liaoning, China
⁵Department of Pathology and Pathophysiology, Tongji University School of Medicine, Shanghai, China
⁶Research Units of Origin and Regulation of Heart Rhythm, Chinese Academy of Medical Sciences, Shanghai, China
^†These authors contributed equally: Duanyang Xie, Ke Xiong, Xuling Su, Guanghua Wang, Qicheng Zou
Correspondence: Yi-Han Chen(yihanchen@tongji.edu.cn)

The sinoatrial node (SAN) is the origin of the electrical signals for rhythmic heartbeats in mammals. The spontaneous firing of SAN pacemaker cells (SANPCs) triggers cardiac contraction. ‘Local Ca2+ release’ (LCR), a unique cellular activity, acts as the ‘engine’ of the spontaneous firing of SANPCs. However, the mechanism of LCR initiation remains unclear. Here, we report that endogenous glutamate drives LCRs in SANPCs. Using a glutamate sensor, we unraveled a tight correlation between glutamate accumulation and LCR occurr

https://doi.org/10.1038/s41422-022-00693-z

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