Volume 32, No 10, Oct 2022

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 32 Issue 10, October 2022: 871-872

RESEARCH HIGHLIGHTS

Inducing Z-DNA overcomes immune checkpoint blockade resistance

Huipeng Jiao^1,2,* , Manolis Pasparakis^1,2,3,*

¹Institute for Genetics, University of Cologne, Cologne, Germany
²Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany
³Center for Molecular Medicine (CMMC), University of Cologne, Cologne, Germany
Correspondence: Huipeng Jiao(jiaohuipeng2006@gmail.com)Manolis Pasparakis(pasparakis@uni-koeln.de)

Inducing immunogenic cell death in tumors holds promise in stimulating anti-tumor immunity. A recent study published in Nature reported that a small molecule previously shown to induce the formation of Z-DNA activates ZBP1-dependent cell death and renders tumors sensitive to immune checkpoint blockade-based immunotherapy.

https://doi.org/10.1038/s41422-022-00705-y

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