Volume 32, No 9, Sep 2022

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 32 Issue 9, September 2022: 795-796

RESEARCH HIGHLIGHTS

R-2-HG assists IDH1-mutant solid tumors by promoting angiogenesis

Nuray Bögürcü-Seidel¹ , Gabriele Bergers^1,2,*

¹Laboratory of Tumor Microenvironment and Therapeutic Resistance, VIB Center for Cancer Biology, Leuven, Belgium
²Department of Oncology, KU Leuven, Leuven, Belgium
Correspondence: Gabriele Bergers(gabriele.bergers@kuleuven.be)

Mutations in isocitrate dehydrogenase lead to the elevated production of the oncometabolite R-2-hydroxyglutarate (R-2-HG), which, albeit insufficient for malignant transformation, exerts intrinsic and paracrine effects that promote tumor propagation and progression. In a recent paper of Cell Research, Wang and colleagues describe a novel extrinsic proangiogenic function of tumor-secreted R-2-HG that, upon uptake by the sodium-dependent glutamate transporter SLC1A1 in tumor endothelial cells, promotes mitochondrial respiration and ATP production leading to enhanced tip cell activity and endothelial cell migration.

https://doi.org/10.1038/s41422-022-00708-9

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