Volume 32, No 11, Nov 2022

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 32 Issue 11, November 2022: 965-966

RESEARCH HIGHLIGHTS

Cofactor-assisted dicing: insights from structural snapshots

Jiamu Du^1,* , Dinshaw J. Patel^2,*

¹Department of Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, Guangdong, China
²Structural Biology Program, Memorial SloanKettering Cancer Center, New York, NY, USA
Correspondence: Jiamu Du(dujm@sustech.edu.cn)Dinshaw J. Patel(pateld@mskcc.org)

Two recent cryo-EM publications in Nature by Su et al. and Yamaguchi et al. have captured snapshots of structures of Drosophila Dicer-2 bound to target dsRNA in the presence of protein cofactors Loquacious-PD or R2D2 along the small RNA biogenesis pathway, thereby highlighting the stepwise molecular mechanism underlying dicing-mediated precise small RNA production.

https://doi.org/10.1038/s41422-022-00716-9

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