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Submit Manuscript Volume 33, No 1, Jan 2023
ISSN: 1001-0602
EISSN: 1748-7838 2018
impact factor 17.848*
(Clarivate Analytics, 2019)
Volume 33 Issue 1, January 2023: 7-8
Proviral role of caspase-6 in coronavirus infections
Lok-Yin Roy Wong , Stanley Perlman*
Department of Microbiology and Immunology, University of Iowa, Iowa City, IA, USAPathogenic human coronaviruses induce apoptosis in infected cells. Caspase-6 activated under apoptotic conditions proteolytically cleaves the nucleocapsid protein into IFN-I antagonists that enhance virus replication, suggesting that caspase-6 has a proviral role in the coronavirus life cycle.
https://doi.org/10.1038/s41422-022-00728-5