Volume 33, No 1, Jan 2023

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 33 Issue 1, January 2023: 7-8

RESEARCH HIGHLIGHTS

Proviral role of caspase-6 in coronavirus infections

Lok-Yin Roy Wong , Stanley Perlman^*

Department of Microbiology and Immunology, University of Iowa, Iowa City, IA, USA
Correspondence: Stanley Perlman(stanley-perlman@uiowa.edu)

Pathogenic human coronaviruses induce apoptosis in infected cells. Caspase-6 activated under apoptotic conditions proteolytically cleaves the nucleocapsid protein into IFN-I antagonists that enhance virus replication, suggesting that caspase-6 has a proviral role in the coronavirus life cycle.

https://doi.org/10.1038/s41422-022-00728-5

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