Volume 33, No 2, Feb 2023

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 33 Issue 2, February 2023: 93-94

RESEARCH HIGHLIGHTS

Adaptation to MOMP drives cancer persistence

Emma Guilbaud¹ , Lorenzo Galluzzi^1,2,3,*

¹Department of Radiation Oncology, Weill Cornell Medical College, New York, NY, USA
²Sandra and Edward Meyer Cancer Center, New York, NY, USA
³Caryl and Israel Englander Institute for Precision Medicine, New York, NY, USA
Correspondence: Lorenzo Galluzzi(deadoc80@gmail.com)

While widespread mitochondrial outer membrane permeabilization (MOMP) generally seals the fate of stressed cancer cells as it elicits caspase-dependent mechanisms that regulate the kinetics and immunological manifestations of cell death, partial MOMP driving sublethal caspase activation has been associated with cancer cell survival in the context of accrued genomic instability. Recent findings delineate a novel caspase-independent mechanism linking sublethal MOMP to the acquisition of a persister phenotype coupled to chemoresistance and accrued metastatic potential.

https://doi.org/10.1038/s41422-022-00729-4

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