Volume 33, No 3, Mar 2023

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 33 Issue 3, March 2023: 189-190

RESEARCH HIGHLIGHTS

mTOR gets greasy: lysosomal sensing of cholesterol

Liron Bar-Peled^1,* , Dudley W. Lamming^2,3,*

¹MGH Cancer Center and Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
²Department of Medicine, University of Wisconsin-Madison, Madison, WI, USA. 3 William S. Middleton Memorial Veterans Hospital, Madison, WI, USA
³William S. Middleton Memorial Veterans Hospital, Madison, WI, USA
Correspondence: Liron Bar-Peled(lbar-peled@mgh.harvard.edu)Dudley W. Lamming(dlamming@medicine.wisc.edu)

The mechanistic Target of Rapamycin Complex 1 (mTORC1) regulates diverse metabolic processes in response to nutrient stimuli and environmental cues. In a recent issue of Science, Shin et al. report the identification of a lysosomal G protein-coupled receptor-like protein that binds to cholesterol and couples the availability of this critical macronutrient to mTORC1 activation.

https://doi.org/10.1038/s41422-022-00740-9

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