Volume 32, No 12, Dec 2022

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 32 Issue 12, December 2022: 1047-1067   |  Open Access

ORIGINAL ARTICLES

Integrated proteogenomic characterization across major histological types of pituitary neuroendocrine tumors

Fan Zhang^1,2,† , Qilin Zhang^1,2,3,†,* , Jiajun Zhu^1,2,† , Boyuan Yao^1,2,3,† , Chi Ma^4,† , Nidan Qiao^1,2,3,† , Shiman He^1,2,† , Zhao Ye^1,2,3,† , Yunzhi Wang^1,2 , Rui Han^1,2,3 , Jinwen Feng^1,2 , Yongfei Wang^1,2,3 , Zhaoyu Qin^1,2 , Zengyi Ma^1,2,3 , Kai Li^1,2 , Yichao Zhang^1,2,3 , Sha Tian^1,2 , Zhengyuan Chen^1,2,3 , Subei Tan^1,2 , Yue Wu^3,5 , Peng Ran^1,2 , Ye Wang^1,2,3 , Chen Ding^1,2,* , Yao Zhao^{1,2,3,6,7,8,9,*}

¹State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Institute of Biomedical Sciences, Human Phenome Institute, Zhongshan Hospital, Fudan University, Shanghai, China
²State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Institute of Biomedical Sciences, Human Phenome Institute, Zhongshan Hospital, Fudan University, Shanghai, China
³National Center for Neurological Disorders, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China
⁴State Key Laboratory of Cell Differentiation and Regulation, Henan International Joint Laboratory of Pulmonary Fibrosis, Henan center for outstanding overseas scientists of pulmonary fibrosis, College of Life Science, Institute of Biomedical Science, Henan Normal University, Xinxiang, Henan, China
⁵Department of Radiology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China
⁶State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Fudan University, Shanghai, China
⁷Shanghai Key laboratory of Brain Function Restoration and Neural Regeneration, Shanghai, China
⁸Neurosurgical Institute of Fudan University, Shanghai, China
⁹National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai, China
^†These authors contributed equally: Fan Zhang, Qilin Zhang, Jiajun Zhu, Boyuan Yao, Chi Ma, Nidan Qiao, Shiman He, Zhao Ye
Correspondence: Qilin Zhang(zhangqlhuashan@163.com)Chen Ding(chend@fudan.edu.cn)Yao Zhao(zhaoyaohs@vip.sina.com)

Pituitary neuroendocrine tumor (PitNET) is one of the most common intracranial tumors. Due to its extensive tumor heterogeneity and the lack of high-quality tissues for biomarker discovery, the causative molecular mechanisms are far from being fully defined. Therefore, more studies are needed to improve the current clinicopathological classification system, and advanced treatment strategies such as targeted therapy and immunotherapy are yet to be explored. Here, we performed the largest integrative genomics, transcriptomics, proteomics, and phosphoproteomics analysis reported to date for a cohort of 200 PitNET patients. Genomics data indicate that GNAS
https://doi.org/10.1038/s41422-022-00736-5

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