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Submit Manuscript Volume 33, No 4, Apr 2023
ISSN: 1001-0602
EISSN: 1748-7838 2018
impact factor 17.848*
(Clarivate Analytics, 2019)
Volume 33 Issue 4, April 2023: 271-272
tRNA-m1A modification: a translational checkpoint for T cell expansion
Weike Pei1,2,* , Vijay K. Kuchroo3,4,*
1Center for Infectious Disease Research, Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, Zhejiang, ChinaAs the major effector cells for protecting the host from pathogens, T cells are required to meet massive demands of proteins to expand themselves quickly upon activation. In a recent paper published in Nature Immunology, Liu et al. reported that the m1A modification of transfer RNA can promote CD4+ T cell proliferation by enhancing the translation efficiency of a specific group of messenger RNAs, providing a new mechanism of translational control of T cell expansion.
https://doi.org/10.1038/s41422-022-00764-1