Volume 33, No 1, Jan 2023

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 33 Issue 1, January 2023: 9-10

RESEARCH HIGHLIGHTS

A ‘warhorse-shaped’ topology adopted by the m6A RNA writer complex

Wei Xie^1,2,* , Dinshaw J. Patel^3,*

¹College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang, China
²Department of Infectious Diseases, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, China
³Structural Biology Program, Memorial Sloan-Kettering Cancer Center, New York, NY, USA
Correspondence: Wei Xie(xie_wei@zju.edu.cn)Dinshaw J. Patel(pateld@mskcc.org)

The m6A writer complex is a holoenzyme formed by catalytic MAC and regulatory MACOM subcomplexes that play a key role in the readout of this most prevalent epigenetic mark on RNA. Su et al. recently determined the cryo-EM structures of the MACOM complex at high resolution and the MAC–MACOM complex at medium resolution, thereby defining the composition and assembly of the core MACOM complex, as well as highlighting insights into the regulatory mechanism of m6A RNA readout at the molecular level and its impact on function.

https://doi.org/10.1038/s41422-022-00748-1

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