Volume 33, No 2, Feb 2023

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 33 Issue 2, February 2023: 87-88

RESEARCH HIGHLIGHTS

A new route for EV biogenesis.

Li Yu^*

State Key Laboratory of Membrane Biology, Tsinghua University–Peking University Joint Center for Life Sciences, Beijing Frontier Research Center for Biological Structure, School of Life Sciences, Tsinghua University, Beijing, China
Correspondence: Li Yu(liyulab@mail.tsinghua.edu.cn)

Exosomes are known to be generated in multivesicular bodies, a subset of endosomes. A recent study by Gao and colleagues uncovers a new type of small extracellular vesicle, which is generated by a different route involving non-canonical autophagy and a previously unknown intermediate organelle named by the authors as RAB22A-mediated non-canonical autophagosome fused with early endosome (Rafeesome).

https://doi.org/10.1038/s41422-022-00747-2

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