Volume 33, No 3, Mar 2023

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 33 Issue 3, March 2023: 199-200

RESEARCH HIGHLIGHTS

Death receptor 5 rises to the occasion

Lixin Zheng^1,2,* , Yikun Yao^1,2,* , Michael J. Lenardo^1,2,*

¹Molecular Development of the Immune System Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
²Clinical Genomics Program, National Institute of Allergy and Infectious Diseases, Bethesda, MD, USA
Correspondence: Lixin Zheng(lizheng@nih.gov)Yikun Yao(yikun.yao@nih.gov)Michael J. Lenardo(lenardo@nih.gov)

Death receptors (DRs), mediate death and inflammation in many cell types, especially in the immune system. In a study published in Cell Research , Du et al. present new structures of lipid membrane-anchored DR5 ectodomains (ECDs) leading to a new model of self-associated DR5 ECDs lying horizontal to the membrane prior to ligand engagement, termed pre-ligand self-association.

https://doi.org/10.1038/s41422-022-00772-1

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