Volume 33, No 4, Apr 2023

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 33 Issue 4, April 2023: 267-268

RESEARCH HIGHLIGHTS

Life mimics art

Muthukumaran Venkatachalapathy¹ , Craig M. Crews^1,2,3,*

¹Department of Molecular, Cellular & Developmental Biology, Yale University, New Haven, CT, USA
²Department of Pharmacology, Yale University, New Haven, CT, USA
³Department of Chemistry, Yale University, New Haven, CT, USA
Correspondence: Craig M. Crews(craig.crews@yale.edu)

Ichikawa et al. have discovered that C-terminal cyclic imides imitate the chemical motif of molecular glue degrader thalidomide and act as a naturally occurring degron of the E3 ligase cereblon.

https://doi.org/10.1038/s41422-022-00765-0

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