Volume 33, No 3, Mar 2023

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 33 Issue 3, March 2023: 191-192

RESEARCH HIGHLIGHTS

Buckle up! How the nano-seatbelt MRAP1 fastens ACTH in its orthosteric seat

Daniel Hilger^*

Department of Pharmaceutical Chemistry, Philipps-University Marburg, Marburg, Germany
Correspondence: Daniel Hilger(daniel.hilger@uni-marburg.de)

Specific binding of the adrenocorticotropic hormone (ACTH) to the melanocortin-2 receptor (MC2R) requires the presence of the melanocortin-2 receptor accessory protein 1 (MRAP1) to induce stress responses via adrenal synthesis and secretion of glucocorticoids. In a recent study published in Cell Research, Luo et al. determined the cryo-EM structure of the ACTH-bound MC2R in complex with the heterotrimeric G protein Gs and MRAP1, which provides important new insights into the molecular mechanism of accessory protein-dependent regulation of ligand binding and signaling of G protein-coupled receptors.

https://doi.org/10.1038/s41422-022-00767-y

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