Advanced Search
Submit Manuscript Volume 33, No 5, May 2023
ISSN: 1001-0602
EISSN: 1748-7838 2018
impact factor 17.848*
(Clarivate Analytics, 2019)
Volume 33 Issue 5, May 2023: 335-336
Mitochondrial PD-L1 modulates cancer immunotherapy
Xiaoming Dai1,† , Jing Liu1,† , Wenyi Wei1,*
1Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USAThe expression and subcellular localization of immune checkpoint protein PD-L1 have been implicated to play an important role in cancer immunotherapy. In a recent paper published in Cell Research, Xie et al. report that promoting mitochondrial distribution of PD-L1 through targeting the ATAD3A-PINK1-mitophagy axis is a promising strategy to overcome chemoimmunotherapy resistance.
https://doi.org/10.1038/s41422-023-00777-4