Volume 33, No 4, Apr 2023

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 33 Issue 4, April 2023: 269-270

RESEARCH HIGHLIGHTS

Transcription initiation by the ERRs: no ligand but two activation pathways

Vincent Giguère^*

Goodman Cancer Institute and Department of Biochemistry, Faculty of Medicine, McGill University, Montréal, QC, Canada
Correspondence: Vincent Giguère(vincent.giguere@mcgill.ca)

Estrogen-related receptors (ERRα, β and γ) are orphan nuclear receptors that control the transcription of genes involved in the production of cellular energy in response to developmental and physiological cues. Nakadai and colleagues now demonstrate that ERR isoforms utilize two complementary mechanisms to induce distinct gene programs: one dependent on a direct interaction with the p52 subunit of the initiation factor TFIIH, the other contingent on the presence of cell-specific coactivators to recruit p300 and Mediator to ERR-bound promoters.

https://doi.org/10.1038/s41422-023-00780-9

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