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Volume 33, No 5, May 2023

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 33 Issue 5, May 2023: 333-334


ZBP1 inflames the SARS-CoV-2-infected lung

Chaoran Yin , Siddharth Balachandran*

Fox Chase Cancer Center, Philadelphia, PA, USA
Correspondence: Siddharth Balachandran(

The innate immune sensor Z-form nucleic acid binding protein 1 (ZBP1) detects Z-RNAs and induces Receptor Interacting Protein Kinase 3 (RIPK3)-driven pathways of cell death and inflammation during acute virus infections. In a recent paper published in Cell Research, Li et al. report that SARS-CoV-2 infections generate Z-RNAs and activate ZBP1/RIPK3-mediated necroptosis and inflammation, leading to lung injury in a mouse model.


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