Volume 33, No 4, Apr 2023

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 33 Issue 4, April 2023: 263-264

RESEARCH HIGHLIGHTS

cGASing mitochondria to fend off ferroptosis

Hua Wan , Xuejun Jiang^*

Cell Biology Program, Memorial Sloan Kettering Cancer Center, 1275 York Ave., New York, NY, USA
Correspondence: Xuejun Jiang(jiangx@mskcc.org)

Induction of ferroptosis, a form of non-apoptotic cell death caused by phospholipid peroxidation and consequent plasma membrane rupture, has been explored as a potential strategy for cancer therapy. In a recent paper published in Cell Research, Qiu et al. report that promoting mitochondria-associated cGAS (cyclic GMP-AMP synthase) signal can block ferroptosis to support cancer progression independently of downstream activation of signaling adapter STING (stimulator of interferon genes).

https://doi.org/10.1038/s41422-023-00791-6

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