Volume 33, No 5, May 2023
EISSN: 1748-7838 2018
impact factor 17.848*
(Clarivate Analytics, 2019)
Volume 33 Issue 5, May 2023: 331-332
Positively charged patches: tonic for CAR fitness
Meraj H. Khan , Jan Joseph Melenhorst*Cell Therapy & Immuno-Engineering Program, Center for ImmunoTherapy & Precision Immuno-Oncology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA
Tonic signaling is a constitutive low-level activation of chimeric antigen receptors (CARs) in the absence of tumor antigen and plays an imperative role in the CAR-T efficacy. In a recent paper published in Cell Research, Chen et al. show that the positively charged patches on the surface of the CAR antigen-binding domain regulate CAR tonic signaling and open a door to further optimization of improvements of CAR.