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Volume 33, No 5, May 2023

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 33 Issue 5, May 2023: 331-332


Positively charged patches: tonic for CAR fitness

Meraj H. Khan , Jan Joseph Melenhorst*

Cell Therapy & Immuno-Engineering Program, Center for ImmunoTherapy & Precision Immuno-Oncology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA
Correspondence: Jan Joseph Melenhorst(

Tonic signaling is a constitutive low-level activation of chimeric antigen receptors (CARs) in the absence of tumor antigen and plays an imperative role in the CAR-T efficacy. In a recent paper published in Cell ResearchChen et al. show that the positively charged patches on the surface of the CAR antigen-binding domain regulate CAR tonic signaling and open a door to further optimization of improvements of CAR.


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