Volume 33, No 6, Jun 2023

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 33 Issue 6, June 2023: 413-414

RESEARCH HIGHLIGHTS

Hematopoietic heterogeneity starts at the hemogenic endothelium

Eline Lemerle , Eirini Trompouki^*

IRCAN Institute for Research on Cancer and Aging, INSERM Unité 1081, CNRS UMR 7284, Université Côte d’Azur, Nice, France
Correspondence: Eirini Trompouki(etrompouki@unice.fr)

Hematopoietic stem cells are heterogenous during development and adulthood; however, when and how this heterogeneity begins is still not well understood. In a new study published in Cell Research, Xia et al. show that hemogenic endothelial cells are heterogeneous and the transcription factor SPI1 in mammals or Spi2 in zebrafish is partially responsible for the establishment of this heterogeneity.

https://doi.org/10.1038/s41422-023-00806-2

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