Volume 33, No 9, Sep 2023

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 33 Issue 9, September 2023: 659-660

RESEARCH HIGHLIGHTS

Towards clinically meaningful expansion of human HSCs

Maria Florencia Tellechea , Jalila Chagraoui , Sandra Cohen , Guy Sauvageau^*

Institute for Research in Immunology and Cancer, University of Montreal, Montreal, QC, Canada
Correspondence: Guy Sauvageau(guy.sauvageau@umontreal.ca)

Improved strategies for ex vivo expansion of human hematopoietic stem cells (HSCs) are necessary to supply the large demand of cells required for certain clinical applications such as gene therapy/editing and cord blood (CB) transplantation. In a recent paper published in Nature, Sakurai et al. reported that the combination of three small molecules, namely a phosphoinositide 3-kinase activator peptide, a thrombopoietin receptor agonist and the pyrimidoindole derivative UM171, was sufficient to stimulate the expansion of umbilical CB HSCs, providing the first chemically defined cytokine-free expansion medium for human HSCs.

https://doi.org/10.1038/s41422-023-00817-z

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