Volume 33, No 8, Aug 2023

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 33 Issue 8, August 2023: 577-578

RESEARCH HIGHLIGHTS

A phosphoinositide kinase triggers migrasome formation

Yan Zhen^1,2,* , Harald Stenmark^1,2,*

¹Centre for Cancer Cell Reprogramming, Faculty of Medicine, University of Oslo, Montebello, Oslo, Norway
²Department of Molecular Cell Biology, Institute for Cancer Research, Oslo University Hospital, Montebello, Oslo, Norway
Correspondence: Yan Zhen(yazhe@medisin.uio.no)Harald Stenmark(stenmark@ulrik.uio.no)

Migrating cells leave behind them a trace of large vesicles known as migrasomes, which are formed from retraction fibers by mechanisms that are incompletely understood. Now, Ding et al. show that the phosphoinositide PIP2 orchestrates clustering of integrin molecules at sites of migrasome formation, suggesting that the phosphoinositide kinase that produces PIP2 is the trigger of migrasome biogenesis.

https://doi.org/10.1038/s41422-023-00822-2

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