Volume 33, No 8, Aug 2023
ISSN: 1001-0602
EISSN: 1748-7838 2018
impact factor 17.848*
(Clarivate Analytics, 2019)
Volume 33 Issue 8, August 2023: 604-616
ORIGINAL ARTICLES
Structural genomics of the human dopamine receptor system
Peiyu Xu1,10,† , Sijie Huang1,11,† , Brian E. Krumm2,† , Youwen Zhuang1,† , Chunyou Mao3,4,† , Yumu Zhang1,5,6 , Yue Wang1,5 , Xi-Ping Huang2 , Yong-Feng Liu2 , Xinheng He1,5 , Huadong Li1,5,6 , Wanchao Yin1 , Yi Jiang1 , Yan Zhang3,7,8,9,* , Bryan L. Roth2,* , H. Eric Xu1,5,6,*
1State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China
2Department of Pharmacology, University of North Carolina Chapel Hill Medical School, Chapel Hill, NC, USA
3Center for Structural Pharmacology and Therapeutics Development, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China
4Department of General Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China
5University of Chinese Academy of Sciences, Beijing, China
6School of Life Science and Technology, ShanghaiTech University, Shanghai, China
7Department of Biophysics and Department of Pathology of Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China
8MOE Frontier Science Center for Brain Research and Brain-Machine Integration, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China
9Liangzhu Laboratory, Zhejiang University Medical Center, Hangzhou, Zhejiang, China
10Present address: McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA, USA
11Present address: Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, CA, USA
†These authors contributed equally: Peiyu Xu, Sijie Huang, Brian E. Krumm, Youwen Zhuang, Chunyou Mao
Correspondence: Yan Zhang(zhang_yan@zju.edu.cn)Bryan L. Roth(bryan_roth@med.unc.edu)H. Eric Xu(eric.xu@simm.ac.cn)
The dopaminergic system, including five dopamine receptors (D1R to D5R), plays essential roles in the central nervous system...
https://doi.org/10.1038/s41422-023-00808-0
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