Volume 33, No 10, Oct 2023

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 33 Issue 10, October 2023: 739-740

RESEARCH HIGHLIGHTS

CAR T cell design: approaching the elusive AND-gate

Zeguo Zhao , Michel Sadelain^*

Center for Cell Engineering and Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA
Correspondence: Michel Sadelain(m-sadelain@ski.mskcc.org)

Logic gating is a strategy for chimeric antigen receptor (CAR) T cell therapy to target tumor cells that lack tumor-specific antigens and prevent on-target/off-tumor toxicity. In a recent Nature article, Tousley et al. present an elegant CAR T cell AND-gate design to enhance CAR T cell safety without compromising efficacy.

https://doi.org/10.1038/s41422-023-00828-w

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