Volume 33, No 8, Aug 2023

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 33 Issue 8, August 2023: 640-643

LETTERS TO THE EDITOR

YBX2-dependent stabilization of oocyte mRNA through a reversible sponge-like cortical partition

Zhihua Zhang^1,†,* , Ruyi Liu^1,† , Hongbin Zhou^1,† , Yuxi Luo¹ , Jian Mu¹ , Jing Fu² , Tianyu Wu¹ , Biaobang Chen³ , Qing Sang^1,* , Lei Wang^1,*

¹Institute of Pediatrics, Children’s Hospital of Fudan University, the Institutes of Biomedical Sciences, The State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, China
²Shanghai Ji Ai Genetics and IVF Institute, Obstetrics and Gynecology Hospital, Fudan University, Shanghai, China
³NHC Key Lab of Reproduction Regulation (Shanghai Institute for Biomedical and Pharmaceutical Technologies), Fudan University, Shanghai, China
^†These authors contributed equally: Zhihua Zhang, Ruyi Liu, Hongbin Zhou
Correspondence: Zhihua Zhang(zhihuazhang16@fudan.edu.cn)Qing Sang(sangqing@fudan.edu.cn)Lei Wang(wangleiwanglei@fudan.edu.cn)

Dear Editor,

Oocyte meiotic maturation and early embryogenesis occur in the absence of transcription and rely on maternal mRNA stored in oocytes.1 In mice, the transcription is subsequently silenced from the late germinal vesicle (GV) stage until embryonic genome activation at the 2-cell stage.1 Therefore, during early oocyte growth, the oocyte must accumulate essential mRNA transcripts to support subsequent oocyte maturation, meiosis, and early embryo development. The growth period of mouse oocytes is usually 22–24 days, and the mRNA synthesized and stored during this time is remarkably stable with a half-life of nearly 2 weeks.2 In contrast, the half-life of most mRNA in mouse embryonic stem cells is less than 24 h.3 Thus, the exact mechanism for how the maternal mRNA in oocytes maintains their long-term stability remains unclear.

https://doi.org/10.1038/s41422-023-00824-0

FULL TEXT | PDF

Browse 522