Volume 33, No 11, Nov 2023

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 33 Issue 11, November 2023: 819-820

RESEARCH HIGHLIGHTS

GPCRs and β-arrestins — an on-off relationship

Alex R. B. Thomsen^1,2,*

¹Department of Molecular Pathobiology, New York University College of Dentistry, New York, NY, USA
²NYU Pain Research Center, New York University College of Dentistry, New York, NY, USA
Correspondence: Alex R. B. Thomsen(art8@nyu.edu)

Traditionally, G protein-coupled receptor (GPCR)-mediated G protein signaling has been thought to be terminated by receptor phosphorylation followed by recruitment of β-arrestins, which uncouples G protein from the receptor. However, new detailed insights published in Cell by Grimes et al. suggest that the initial agonist-stimulated β-arrestin accumulation at the cell membrane and GPCR–β-arrestin association are mechanistically distinct and much more dynamic than previously appreciated.

https://doi.org/10.1038/s41422-023-00838-8

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