Volume 33, No 8, Aug 2023

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 33 Issue 8, August 2023: 581-582

RESEARCH HIGHLIGHTS

6mA-METL-9 axis regulates innate immunity in C. elegans

Tong Wu^1,2 , Chuan He^1,2,3,*

¹Department of Chemistry, The University of Chicago, Chicago, IL, USA
²Howard Hughes Medical Institute, The University of Chicago, Chicago, IL, USA
³Department of Biochemistry and Molecular Biology, Institute for Biophysical Dynamics, The University of Chicago, Chicago, IL, USA
Correspondence: Chuan He(chuanhe@uchicago.edu)

While prevalent in prokaryotes, physiological function and potential regulation of DNA 6mA modification in eukaryotes have yet to be fully explored. In a new study published in Cell Research, Ma et al. identified METL-9 as a DNA 6mA methyltransferase in Caenorhabditis elegans, and demonstrated that METL-9 could regulate innate immunity through 6mA-dependent and -independent pathways, suggesting new mechanisms for combating pathogen infection in eukaryotes.

https://doi.org/10.1038/s41422-023-00837-9

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