Volume 33, No 10, Oct 2023

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 33 Issue 10, October 2023: 735-736

RESEARCH HIGHLIGHTS

Steering G protein activation by mGlu heterodimer

Guillaume Lebon^*

Institut de Génomique Fonctionnelle, Univeristé de Montpellier, CNRS, INSERM, Montpellier, France
Correspondence: Guillaume Lebon(guillaume.lebon@igf.cnrs.fr)

Heterodimerization of metabotropic glutamate receptors (mGlus) generates functional units that modulate the synapse activity, and displays strong therapeutic potential for treating brain disorders and psychiatry diseases. Here, Wang et al. solved the cryo-EM structures of mGlu2–mGlu3, and mGlu2–mGlu4 heterodimers in various conformational states, revealing the role of each subunit in the asymmetric signaling of mGlu heterodimers and the molecular basis of their allosteric modulation, and giving a rationale to understand which subunit activates the G protein.

https://doi.org/10.1038/s41422-023-00843-x

FULL TEXT | PDF

Browse 542