Volume 33, No 8, Aug 2023

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 33 Issue 8, August 2023: 575-576

RESEARCH HIGHLIGHTS

Senolysis through thrombomodulation

Corey M. Webster¹ , Jan M. van Deursen^2,*

¹Buck Institute for Research on Aging, Novato, CA, USA. 2 Cavalry Biosciences, Novato and San Francisco, CA, USA
²Cavalry Biosciences, Novato and San Francisco, CA, USA
Correspondence: Jan M. van Deursen(cwebster@buckinstitute.org)

In a recent study published in Cell Research, Pan et al. show that thrombomodulin (THBD), a cell surface glycoprotein activator of the thrombin-mediated MAPK pathway, is a key determinant of senescent cell fate. Using the FDA-approved THBD pathway inhibitor, vorapaxar, or depletion of THBD signaling, they show that inhibition or depletion of the THBD pathway acts as a novel senolytic mechanism and restores homeostasis in liver fibrosis models.

https://doi.org/10.1038/s41422-023-00842-y

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