Volume 33, No 9, Sep 2023

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 33 Issue 9, September 2023: 651-652

RESEARCH HIGHLIGHTS

Unveiling the hidden battlefield: dissecting the invasive zone in liver cancer

Valerie Chew^*

Translational Immunology Institute (TII), SingHealth-DukeNUS Academic Medical Centre, Singapore, Singapore
Correspondence: Valerie Chew(valerie.chew@duke-nus.edu.sg)

Understanding the tumor ecosystem, particularly the tumor invasive margins, is crucial for studying tumor progression and metastasis. Using nanoscale-resolution SpaTial Enhanced REsolution Omics-sequencing (Stereo-seq), Wu et al. identified an invasive zone around the tumor border in liver cancer patients characterized by the overexpression of serum amyloid A1 and A2, which is associated with immunosuppression and poor prognosis.

https://doi.org/10.1038/s41422-023-00855-7

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