Volume 33, No 12, Dec 2023

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 33 Issue 12, December 2023: 898-899

RESEARCH HIGHLIGHTS

Uridine: as sweet as sugar for some cells?

Matthew H. Ward^1,2 , Zeribe C. Nwosu³ , Costas A. Lyssiotis^3,4,5,*

¹Department of Chemistry, Washington University in St. Louis, St. Louis, MO, USA
²Department of Medicine, Washington University in St. Louis, St. Louis, MO, USA
³Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI, USA
⁴Department of Internal Medicine, Division of Gastroenterology, University of Michigan, Ann Arbor, MI, USA
⁵Rogel Cancer Center, University of Michigan, Ann Arbor, MI, USA
Correspondence: Costas A. Lyssiotis(clyssiot@med.umich.edu)

Nucleosides fuel mammalian cell energy needs and biosynthetic pathways such as ribosylation, glycosylation, redox metabolite generation, and nucleotide biosynthesis. Two recent studies published in Nature Metabolism and Nature follow distinct screening approaches to reveal that uridine, a pyrimidine nucleoside, maintains metabolic homeostasis during growth and cellular stress.

https://doi.org/10.1038/s41422-023-00860-w

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