Volume 33, No 11, Nov 2023

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 33 Issue 11, November 2023: 811-812

RESEARCH HIGHLIGHTS

RHIMoving fibrils of death

Bart Tummers^*

Centre for Inflammation Biology & Cancer Immunology (CIBCI), Department of Inflammation Biology, School of Immunology & Microbial Sciences, King’s College London, London, UK
Correspondence: Bart Tummers(bart.tummers@kcl.ac.uk)

Necroptosis relies on interactions between RIP Homotypic Interaction Motif (RHIM)-containing proteins to form an RHIM-amyloid structure called the necrosome. Recent findings by Wu et al. in Cell Research now demonstrate that HSPA8, a member of the 70-kDa heat shock protein (HSP70) family, negatively regulates necroptosis by inhibiting and reversing RHIM-amyloid fibril formation, thereby safeguarding tissues from damage.

https://doi.org/10.1038/s41422-023-00875-3

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