Volume 34, No 1, Jan 2024

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 34 Issue 1, January 2024: 7-8

RESEARCH HIGHLIGHTS

Chromosomal instability drives immunosuppression and metastatic dissemination

Ilio Vitale^1,2,* , Claudia Galassi³ , Lorenzo Galluzzi^3,4,5,*

¹IIGM-Italian Institute for Genomic Medicine, c/o IRCSS Candiolo, Torino, Italy
²Candiolo Cancer Institute, FPO-IRCCS, Candiolo, Italy
³Department of Radiation Oncology, Weill Cornell Medical College, New York, NY, USA
⁴Sandra and Edward Meyer Cancer Center, New York, NY, USA
⁵Caryl and Israel Englander Institute for Precision Medicine, New York, NY, USA
Correspondence: Ilio Vitale(iliovit@gmail.com)Lorenzo Galluzzi(deadoc80@gmail.com)

Chromosomal instability (CIN) contributes to tumor initiation, progression, and metastatic dissemination. In a recent issue of Nature, Li et al. characterized a cancer cell-heterologous mechanism through which CIN drives metastasis upon the rewiring of cGAS-STING1 signaling in cancer cells and the consequent establishment of local immunosuppression.

https://doi.org/10.1038/s41422-023-00876-2

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