Volume 33, No 12, Dec 2023

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 33 Issue 12, December 2023: 975-978

LETTERS TO THE EDITOR

A broadly neutralizing antibody inhibits SARS-CoV-2 variants through a novel mechanism of disrupting spike trimer integrity

Yunping Ma^1,2,† , Qiyu Mao^1,† , Yingdan Wang^1,† , Zhaoyong Zhang^3,† , Jiali Chen¹ , Aihua Hao¹ , Palizhati Rehati¹ , Yanqun Wang³ , Yumei Wen¹ , Lu Lu¹ , Zhenguo Chen¹ , Jincun Zhao^3,4,* , Fan Wu^2,* , Lei Sun^1,* , Jinghe Huang^1,*

¹Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS) and Shanghai Institute of Infectious Disease and Biosecurity, Shanghai Public Health Clinical Center, Shanghai Fifth People’s Hospital, Institutes of Biomedical Sciences, School of Basic Medical Sciences, Fudan University, Shanghai, China
²Shanghai Immune Therapy Institute, Shanghai Jiao Tong University School of Medicine Affiliated Renji Hospital, Shanghai, China
³State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China
⁴Shanghai Institute for Advanced Immunochemical Studies, School of Life Science and Technology, Shanghai Tech University, Shanghai, China
^†These authors contributed equally: Yunping Ma, Qiyu Mao, Yingdan Wang, Zhaoyong Zhang
Correspondence: Jincun Zhao(zhaojincun@gird.cn)Fan Wu(wufan@fudan.edu.cn)Lei Sun(llsun@fudan.edu.cn)Jinghe Huang(Jinghehuang@fudan.edu.cn)

https://doi.org/10.1038/s41422-023-00880-6

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