Volume 34, No 3, Mar 2024

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 34 Issue 3, March 2024: 189-190

RESEARCH HIGHLIGHTS

Humanizing pig kidneys via chimeric complementation

Jia Huang¹ , Jun Wu^1,2,3,*

¹Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX, USA
²Hamon Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA
³Cecil H. and Ida Green Center for Reproductive Biology Sciences, University of Texas Southwestern Medical Center, Dallas, TX, USA
Correspondence: Jun Wu(jun2.wu@utsouthwestern.edu)

An ultimate goal in stem cell research is to use induced pluripotent stem cells (iPSCs) to generate transplantable human organs in large livestock. In a groundbreaking study by Wang et al., the researchers showcased that by combining an optimized iPSC culture, tactics to boost the survival and competitive edge of donor human cells, and a genetically vacated host organ niche, they could successfully produce a humanized mesonephros within pig fetuses, a significant leap in the field.

https://doi.org/10.1038/s41422-023-00881-5

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