Volume 33, No 12, Dec 2023

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 33 Issue 12, December 2023: 894-895

RESEARCH HIGHLIGHTS

An idle PHGDH takes control of cell fate

Linchong Sun^* , Ping Gao^*

Medical Research Institute, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, Guangdong, China
Correspondence: Linchong Sun(sunlc@mail.ustc.edu.cn)Ping Gao(pgao2@ustc.edu.cn)

Multifunctional metabolites are widely involved in physiological and pathological processes as signaling molecules, sensors, epigenetic modification substrates and so on, in addition to being energy substances. In a recent Cell Research study, Wu et al. make a remarkable discovery that, when the level of 3-phosphoglycerate, a typical metabolite at the crossroads of glucose catabolism and serine anabolism, is low, the unoccupied 3-phosphoglycerate dehydrogenase is redirected to watch the cell fate.

https://doi.org/10.1038/s41422-023-00883-3

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