Volume 34, No 3, Mar 2024

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 34 Issue 3, March 2024: 187-188

RESEARCH HIGHLIGHTS

Hematopoietic memory of severe COVID-19 infection

Anaisa V. Ferreira¹ , Mihai G. Netea^1,2,*

¹Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, The Netherlands
²Department of Immunology and Metabolism, Life and Medical Sciences Center, University of Bonn, Bonn, Germany
Correspondence: Mihai G. Netea(Mihai.Netea@radboudumc.nl)

A new study describes that individuals who recovered from severe coronavirus disease-19 (COVID-19) exhibit long-term epigenetic changes in their hematopoietic stem and progenitor cells, which are subsequently conveyed to circulating progeny myeloid cells. This epigenetic memory of hematopoietic cells is partly mediated by IL-6 induction in the acute phase of the infection and may account for the long-term altered myeloid cell function after COVID-19.

https://doi.org/10.1038/s41422-023-00885-1

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