Volume 34, No 2, Feb 2024

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 34 Issue 2, February 2024: 99-100

RESEARCH HIGHLIGHTS

Fanzors: Striking expansion of RNA-guided endonucleases to eukaryotes

Hui Yang^1,* , Dinshaw J. Patel^2,*

¹Key Laboratory of RNA Science and Engineering, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, China
²Structural Biology Program, Memorial Sloan-Kettering Cancer Center, New York, NY, USA
Correspondence: Hui Yang(yanghui@sibcb.ac.cn)Dinshaw J. Patel(pateld@mskcc.org)

RNA-guided DNA endonucleases are broadly associated with and play critical roles in prokaryotic adaptive immunity-based CRISPR-Cas systems and IS200/605 family transposons. The Feng Zhang lab recently elucidated the phylogeny, enzymatic activity and DNA recognition mechanism of its eukaryotic counterpart Fanzor, while further reprogramming Fanzor for human genome editing applications, thereby highlighting a universal RNA-guided DNA cleavage mechanism spanning from prokaryotes to eukaryotes.

https://doi.org/10.1038/s41422-023-00894-0

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