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Submit Manuscript Volume 34, No 1, Jan 2024
ISSN: 1001-0602
EISSN: 1748-7838 2018
impact factor 17.848*
(Clarivate Analytics, 2019)
Volume 34 Issue 1, January 2024: 1-2
Rpd3S meets the nucleosome
Michael J. Carrozza1,* , Jerry L. Workman2
1Department of Biology, New York University, New York, NY, USATwo recent reports in Cell Research present cryo-electron microscopy structures of the Rpd3S HDAC complex bound to the nucleosome. These structures provide novel insight into the binding properties of the Rpd3S subunits Sin3, Rco1 and Eaf3 to DNA and Rco1 and Eaf3 to unmodified H3K4 and methylated H3K36, respectively, and also provide a fascinating look at the unique properties of Rpd3 in recognizing specific acetylated lysines for deacetylation in the context of Rpd3S.
https://doi.org/10.1038/s41422-023-00899-9