Volume 34, No 2, Feb 2024

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 34 Issue 2, February 2024: 91-92

RESEARCH HIGHLIGHTS

Lactylation constrains OXPHOS under hypoxia

Haowen Ren¹ , Di Zhang^1,2,*

¹State Key Laboratory of Protein and Plant Gene Research, School of Life Sciences, Peking University, Beijing, China
²Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China
Correspondence: Di Zhang(zhangdi@pku.edu.cn)

Cells sense and adapt to oxygen availability. A new study published in Cell Research reports that hypoxia-induced mitochondrial protein lactylation halts oxidative phosphorylation, underscoring the swift cellular response to low oxygen.

https://doi.org/10.1038/s41422-023-00872-6

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