Volume 34, No 2, Feb 2024

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 34 Issue 2, February 2024: 95-96

RESEARCH HIGHLIGHTS

An engineered surrogate poly(A) tail to wag translation initiation

Stefan Lohse¹ , Wilfried Weber^1,2,3,*

¹INM-Leibniz Institute for New Materials, Campus D2 2, 66123 Saarbrücken, Germany
²Department of Materials Science and Engineering, Saarland University, Campus D2 2, 66123 Saarbrücken, Germany
³CIBSS-Centre for Integrative Biological Signalling Studies, University of Freiburg, Schänzlestr. 18, 79104 Freiburg, Germany
Correspondence: Wilfried Weber(Wilfried.weber@leibniz-inm.de)

A novel approach for controlling translation initiation in mammalian cells is demonstrated based on the conditional attachment of eukaryotic translation initiation factor-binding proteins to the 3′ UTR of mRNAs via small molecule-, light-, or protein-responsive interactions. The technology overcomes limitations of previously used transcription-based switches and was shown to be functional in managing diabetes or tumor growth in preclinical animal models.

https://doi.org/10.1038/s41422-023-00903-2

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