Volume 34, No 1, Jan 2024

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 34 Issue 1, January 2024: 9-10

RESEARCH HIGHLIGHTS

Learning human liver biology in humanized mice

Brandon M. Lehrich¹ , Satdarshan P. Monga^1,2,*

¹Division of Experimental Pathology, Department of Pathology and Pittsburgh Liver Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
²Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
Correspondence: Satdarshan P. Monga(smonga@pitt.edu)

A new study describes development of a chimeric mouse liver repopulated with nearly all human hepatic cell types albeit to varying extents. This model yielded novel information on unique human hepatocyte metabolic function which is regulated by local microenvironmental signals, specifically sinusoidal endothelial cell-secreted WNT2.

https://doi.org/10.1038/s41422-023-00877-1

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