Volume 34, No 3, Mar 2024

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 34 Issue 3, March 2024: 183-184

RESEARCH HIGHLIGHTS

A dual-purpose fusion complex in autophagy

Yan Zhen^1,2 , Harald Stenmark^1,2,*

¹Centre for Cancer Cell Reprogramming, Faculty of Medicine, University of Oslo, Montebello, Oslo, Norway
²Department of Molecular Cell Biology, Institute for Cancer Research, Oslo University Hospital, Montebello, Oslo, Norway
Correspondence: Harald Stenmark(stenmark@ulrik.uio.no)

Degradation of cytoplasm by autophagy requires fusion of autophagosomes with lysosomes, a process driven by SNARE proteins. In a recent paper in Cell Research, Jian et al. identify a novel SNAP47-containing SNARE complex which mediates autophagosome–lysosome fusion in both bulk and selective autophagy.

https://doi.org/10.1038/s41422-023-00925-w

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