Volume 34, No 4, Apr 2024

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 34 Issue 4, April 2024: 271-272

RESEARCH HIGHLIGHTS

CCHFV entry via LDLR keeps it ‘ticking’?

Ahmed K. Oraby , David J. Marchant^*

Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, AB T6G 2R3, Canad
Correspondence: David J. Marchant(marchant@ualberta.ca)

Endemic in Africa, the Balkans, the Middle East, and Asia, Crimean-Congo hemorrhagic fever virus (CCHFV) is transmitted from a tick vector to humans and the mortality rates can be as high as 40%. In a recent paper in Cell Research, Xu et al. reports the discovery of LDLR as the CCHFV entry receptor in humans and mice, which may provide clues to the receptor that the virus uses in its tick vector, a major discovery that opens up new and much needed options for therapeutic development.

https://doi.org/10.1038/s41422-024-00928-1

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