Volume 34, No 4, Apr 2024

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 34 Issue 4, April 2024: 273-274

RESEARCH HIGHLIGHTS

Enabling whole pathway reconstruction using artificial chromosomes

Zihe Liu^1,* , Jens Nielsen^1,2,*

¹College of Life Science and Technology, Beijing Advanced Innovation Center for Soft Matter Science and Engineering, Beijing University of Chemical Technology, Beijing, China
²BioInnovation Institute, DK-2200 Copenhagen, Denmark
Correspondence: Zihe Liu(zihe@mail.buct.edu.cn)Jens Nielsen(nielsenj@chalmers.se)

In synthetic biology it is desirable to transfer megabase-scale DNA as this enables introduction of complete biological pathways into a new host organism. A new study in Cell Research reports HAnDy (Haploidization-based DNA Assembly and Delivery in yeast) that enables efficient assembly of a 1.024 Mb artificial chromosome and chromosomal transfer between Saccharomyces species.

https://doi.org/10.1038/s41422-024-00943-2

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