Volume 34, No 8, Aug 2024

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 34 Issue 8, August 2024: 537-538

RESEARCH HIGHLIGHTS

Z-DNA marks the spot for AIRE

Yael Goldfarb^* , Jakub Abramson^*

Department of Immunology and Regenerative Biology, Weizmann Institute of Science, Rehovot, Israel
Correspondence: Yael Goldfarb(yael.goldfarb@weizmann.ac.il)Jakub Abramson(jakub.abramson@weizmann.ac.il)

Autoimmune regulator (AIRE) is a unique transcriptional regulator that induces ectopic expression of thousands of tissue-specific genes in the thymus, a step critical for the establishment of immunological tolerance to self. In their recent publication, Fang et al. provide novel mechanistic insights into AIRE’s modus operandi, by highlighting Z-DNA as a key cis-regulatory element, critical for guiding AIRE to its target genes.

https://doi.org/10.1038/s41422-024-00964-x

FULL TEXT | PDF

Browse 390