Volume 34, No 8, Aug 2024

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 34 Issue 8, August 2024: 543-544

RESEARCH HIGHLIGHTS

ONE-GO: Direct detection of context-dependent GPCR activity

Aleksey Raskovalov^1,2 , Donggyun Kim^1,2 , Vadim Cherezov^1,2,*

¹Department of Chemistry, University of Southern California, Los Angeles, CA, USA
²Bridge Institute, Michelson Center for Convergent Biosciences, University of Southern California, Los Angeles, CA, USA
Correspondence: Vadim Cherezov(cherezov@usc.edu)

G protein-coupled receptors (GPCRs) represent some of the most important drug targets in the human genome, however, our understanding of these receptors has primarily been confined to systems that require the overexpression of target receptors. In a recent study published in Cell, Janicot et al. introduced a universal biosensor platform capable of detecting GPCR signaling at endogenous levels, which facilitates its application across various cell lines, including primary cells, thereby improving our understanding of context-dependent GPCR activity and system bias.

https://doi.org/10.1038/s41422-024-00966-9

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